Genome-wide association study of antidepressant response: involvement of the inorganic cation transmembrane transporter activity pathway.

ABSTRACT:

Background

Genome-wide association studies (GWAS) represent the current frontier in pharmacogenomics. Thousands of subjects of Caucasian ancestry have been included in previous GWAS investigating antidepressant response. GWAS focused on this phenotype are lacking in Asian populations.

Methods

A sample of 109 major depressive disorder (MDD) patients of Korean origin in antidepressant treatment was collected. Phenotypes were response and remission according to the Hamilton Rating Scale for Depression (HRSD). Genome-wide genotyping was performed using the Illumina Human Omni2.5-8 platform. The same phenotypes were used in the STAR*D level 1 (n = 1677) for independent replication. In order to corroborate findings and increase the comparability between the two datasets, three lev

SUBMITTER: Cocchi E 

PROVIDER: S-EPMC4836090 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature