Circulating N-Linked Glycoprotein Acetyls and Longitudinal Mortality Risk.

ABSTRACT:

Rationale

Circulating glycoprotein N-acetyl glucosamine residues have recently been associated with incident cardiovascular disease and diabetes mellitus.

Objective

Using a plasma glycan biosignature (GlycA) to identify circulating N-acetyl glycan groups, we examined the longitudinal association between GlycA and mortality among initially healthy individuals.

Methods and results

We quantified GlycA by 400 MHz (1)H nuclear magnetic resonance spectroscopy in 27,524 participants in the Women's Health Study (NCT00000479). The primary outcome was all-cause mortality. We replicated the findings in an independent cohort of 12,527 individuals in the Justification for the Use of statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial (NCT00239681).

SUBMITTER: Lawler PR 

PROVIDER: S-EPMC4836171 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature