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The emerging role of GATA transcription factors in development and disease.

ABSTRACT: The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

SUBMITTER: Lentjes MH 

PROVIDER: S-EPMC4836206 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature

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The emerging role of GATA transcription factors in development and disease.

Lentjes Marjolein H F M MH   Niessen Hanneke E C HE   Akiyama Yoshimitsu Y   de Bruïne Adriaan P AP   Melotte Veerle V   van Engeland Manon M  

Expert reviews in molecular medicine 20160308

The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance  ...[more]

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