Novel Feline Leukemia Virus Interference Group Based on the env Gene.

ABSTRACT: Feline leukemia virus (FeLV) subgroups have emerged in infected cats via the mutation or recombination of the env gene of subgroup A FeLV (FeLV-A), the primary virus. We report the isolation and characterization of a novel env gene, TG35-2, and report that the TG35-2 pseudotype can be categorized as a novel FeLV subgroup. The TG35-2 envelope protein displays strong sequence identity to FeLV-A Env, suggesting that selection pressure in cats causes novel FeLV subgroups to emerge.

SUBMITTER: Miyake A 

PROVIDER: S-EPMC4836335 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature