Structural Basis for Norovirus Inhibition by Human Milk Oligosaccharides.

ABSTRACT: Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2'FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2'FL and 3FL structurally mimic HBGAs. These results suggest that 2'FL and 3FL might act as naturally occurring decoys in humans.

SUBMITTER: Weichert S 

PROVIDER: S-EPMC4836343 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature