Computed tomography-measured adipose tissue attenuation and area both predict adipocyte size and cardiometabolic risk in women.

ABSTRACT:

Objective

To assess the ability of CT-derived measurements including adipose tissue attenuation and area to predict fat cell hypertrophy and related cardiometabolic risk.

Methods

Abdominal adipose tissue areas and radiologic attenuation were assessed using 4 CT images in 241 women (age: 47 years, BMI: 26.5 kg/m(2)). Fat cell weight was measured in paired VAT and SAT samples. Fasting plasma lipids, glucose and insulin levels were measured.

Results

Adipose tissue attenuation was negatively correlated with SAT (r=-0.46) and VAT (r=-0.67) fat cell weight in the corresponding depot (p<0.0001 for both). Women with visceral adipocyte hypertrophy had higher total-, VLDL-, LDL- and HDL-triglyceride and apoB levels as well as a higher cholesterol/HDL-cholesterol ratio, fasting

SUBMITTER: Cote JA 

PROVIDER: S-EPMC4836459 | biostudies-literature | 2016 Jan-Mar

REPOSITORIES: biostudies-literature