APP Is a Context-Sensitive Regulator of the Hippocampal Presynaptic Active Zone.

ABSTRACT: The hallmarks of Alzheimer's disease (AD) are characterized by cognitive decline and behavioral changes. The most prominent brain region affected by the progression of AD is the hippocampal formation. The pathogenesis involves a successive loss of hippocampal neurons accompanied by a decline in learning and memory consolidation mainly attributed to an accumulation of senile plaques. The amyloid precursor protein (APP) has been identified as precursor of Aβ-peptides, the main constituents of senile plaques. Until now, little is known about the physiological function of APP within the central nervous system. The allocation of APP to the proteome of the highly dynamic presynaptic active zone (PAZ) highlights APP as a yet unknown player in neuronal communication and signaling. In this study, w

SUBMITTER: Laßek M 

PROVIDER: S-EPMC4836664 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature