Tetrabromobisphenol A Is an Efficient Stabilizer of the Transthyretin Tetramer.

ABSTRACT: Amyloid formation of the human plasma protein transthyretin (TTR) is associated with several human disorders, including familial amyloidotic polyneuropathy (FAP) and senile systemic amyloidosis. Dissociation of TTR's native tetrameric assembly is the rate-limiting step in the conversion into amyloid, and this feature presents an avenue for intervention because binding of an appropriate ligand to the thyroxin hormone binding sites of TTR stabilizes the native tetrameric assembly and impairs conversion into amyloid. The desired features for an effective TTR stabilizer include high affinity for TTR, high selectivity in the presence of other proteins, no adverse side effects at the effective concentrations, and a long half-life in the body. In this study we show that the commonly used flame re

SUBMITTER: Iakovleva I 

PROVIDER: S-EPMC4836675 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature