Tacrolimus to Belatacept Conversion Following Hand Transplantation: A Case Report.

ABSTRACT: Vascularized composite allotransplantation (VCA) has emerged as a viable limb replacement strategy for selected patients with upper limb amputation. However, allograft rejection has been seen in essentially all reported VCA recipients indicating a requirement for substantial immunosuppressive therapy. Calcineurin inhibitors have served as the centerpiece agent in all reported cases, and CNI-associated complications associated with the broad therapeutic effects and side effects of calcineurin inhibitors have been similarly common. Recently, belatacept has been approved as a calcineurin inhibitor replacement in kidney transplantation, but to date, its use in VCA has not been reported. Herein, we report on the case of a hand transplant recipient who developed recurrent acute rejection with al

SUBMITTER: Cendales L 

PROVIDER: S-EPMC4836872 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature