Brain arterial aging and its relationship to Alzheimer dementia.

ABSTRACT:

Objective

To test the hypothesis that brain arterial aging is associated with the pathologic diagnosis of Alzheimer disease (AD).

Methods

Brain large arteries were assessed for diameter, gaps in the internal elastic lamina (IEL), luminal stenosis, atherosclerosis, and lumen-to-wall ratio. Elastin, collagen, and amyloid were assessed with Van Gieson, trichrome, and Congo red staining intensities, and quantified automatically. Brain infarcts and AD (defined pathologically) were assessed at autopsy. We created a brain arterial aging (BAA) score with arterial characteristics associated with aging after adjusting for demographic and clinical variables using cross-sectional generalized linear models.

Results

We studied 194 autopsied brains, 25 (13%) of which had autopsy evi

SUBMITTER: Gutierrez J 

PROVIDER: S-EPMC4836884 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature