Determination of neuronal antibodies in suspected and definite Creutzfeldt-Jakob disease.

ABSTRACT:

Importance

Creutzfeldt-Jakob disease (CJD) and autoimmune encephalitis with antibodies against neuronal surface antigens (NSA-abs) may present with similar clinical features. Establishing the correct diagnosis has practical implications in the management of care for these patients.

Objective

To determine the frequency of NSA-abs in the cerebrospinal fluid of patients with suspected CJD and in patients with pathologically confirmed (ie, definite) CJD.

Design, setting, and participants

A mixed prospective (suspected) and retrospective (definite) CJD cohort study was conducted in a reference center for detection of NSA-abs. The population included 346 patients with suspected CJD and 49 patients with definite CJD.

Main outcomes and measures

Analysis of NSA-abs in c

SUBMITTER: Grau-Rivera O 

PROVIDER: S-EPMC4836912 | biostudies-literature | 2014 Jan

REPOSITORIES: biostudies-literature