Hyperactivity of caudate, parahippocampal, and prefrontal regions during working memory in never-medicated persons at clinical high-risk for psychosis.

ABSTRACT:

Background

Deficits in working memory (WM) are a core feature of schizophrenia (SZ) and other psychotic disorders. We examined brain activity during WM in persons at clinical high risk (CHR) for psychosis.

Methods

Thirty-seven CHR and 34 healthy control participants underwent functional MRI (fMRI) on a 3.0T scanner while performing an N-back WM task. The sample included a sub-sample of CHR participants who had no lifetime history of treatment with psychotropic medications (n=11). Data were analyzed using SPM8 (2-back>0-back contrast). Pearson correlations between brain activity, symptoms, and WM performance were examined.

Results

The total CHR group and medication-naive CHR sub-sample were comparable to controls in most demographic features and in N-back WM performanc

SUBMITTER: Thermenos HW 

PROVIDER: S-EPMC4836956 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature