Modular Assembly Approach to Engineer Geometrically Precise Cardiovascular Tissue.

ABSTRACT: This modular assembly approach to microfabricate functional cardiovascular tissue composites enables quantitative assessment of the effects of microarchitecture on cellular function. Cardiac and endothelial modules are micromolded separately, designed to direct cardiomyocyte alignment and anisotropic contraction or vascular network formation. Assembled cardiovascular tissue composites contract synchronously, facilitating the use of this tissue-engineering platform to study structure-function relationships in the heart.

SUBMITTER: Lee BW 

PROVIDER: S-EPMC4836958 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature