Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies.

ABSTRACT:

Objective

To develop a practical evidence based list of clinical risk factors that can be assessed by a clinician at ≤ 16 weeks' gestation to estimate a woman's risk of pre-eclampsia.

Design

Systematic review and meta-analysis of cohort studies.

Data sources

PubMed and Embase databases, 2000-15.

Eligibility criteria for selecting studies

Cohort studies with ≥ 1000 participants that evaluated the risk of pre-eclampsia in relation to a common and generally accepted clinical risk factor assessed at ≤ 16 weeks' gestation.

Data extraction

Two independent reviewers extracted data from included studies. A pooled event rate and pooled relative risk for pre-eclampsia were calculated for each of 14 risk factors.

Results

There were 25,356,688 pregnancies amo

SUBMITTER: Bartsch E 

PROVIDER: S-EPMC4837230 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature