Obesogenic memory can confer long-term increases in adipose tissue but not liver inflammation and insulin resistance after weight loss.

ABSTRACT:

Objective

Obesity represents a major risk factor for the development of type 2 diabetes mellitus, atherosclerosis and certain cancer entities. Treatment of obesity is hindered by the long-term maintenance of initially reduced body weight, and it remains unclear whether all pathologies associated with obesity are fully reversible even upon successfully maintained weight loss.

Methods

We compared high fat diet-fed, weight reduced and lean mice in terms of body weight development, adipose tissue and liver insulin sensitivity as well as inflammatory gene expression. Moreover, we assessed similar parameters in a human cohort before and after bariatric surgery.

Results

Compared to lean animals, mice that demonstrated successful weight reduction showed increased weight gain

SUBMITTER: Schmitz J 

PROVIDER: S-EPMC4837291 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature