Transient potassium channels augment degeneracy in hippocampal active dendritic spectral tuning.

ABSTRACT: Hippocampal pyramidal neurons express an intraneuronal map of spectral tuning mediated by hyperpolarization-activated cyclic-nucleotide-gated nonspecific-cation channels. Modeling studies have predicted a critical regulatory role for A-type potassium (KA) channels towards augmenting functional robustness of this map. To test this, we performed patch-clamp recordings from soma and dendrites of rat hippocampal pyramidal neurons, and measured spectral tuning before and after blocking KA channels using two structurally distinct pharmacological agents. Consistent with computational predictions, we found that blocking KA channels resulted in a significant reduction in resonance frequency and significant increases in input resistance, impedance amplitude and action-potential firing frequency acro

SUBMITTER: Rathour RK 

PROVIDER: S-EPMC4837398 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature