The haplotype of UBE2L3 gene is associated with Hashimoto's thyroiditis in a Chinese Han population.

ABSTRACT:

Background

The ubiquitin conjugating enzyme E2L3 (UBE2L3) gene is associated with susceptibility to many autoimmune diseases. The aim of this study was to investigate the association between UBE2L3 gene and autoimmune thyroid diseases (AITDs) and their clinical phenotypes.

Methods

We genotyped five single-nucleotide polymorphisms (SNPs) rs131654, rs5754217, rs2298428, rs140489 and rs5998672 of UBE2L3 gene in case groups including 1028 patients with AITDs [676 cases of Graves' disease (GD) and 352 cases of Hashimoto's thyroiditis (HT)] and control group including 897 healthy individuals. The genotyping was performed with the method of polymerase chain reaction-ligase detection reaction (PCR-LDR).

Results

The frequencies of allele and genotype of five SNPs in gene UBE2L

SUBMITTER: Wang Y 

PROVIDER: S-EPMC4837539 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature