Associations between joint effusion in the knee and gene expression levels in the circulation: a meta-analysis.

ABSTRACT:

Objective

To identify molecular biomarkers for early knee osteoarthritis (OA), we examined whether joint effusion in the knee associated with different gene expression levels in the circulation.

Materials and methods

Joint effusion grades measured with magnetic resonance (MR) imaging and gene expression levels in blood were determined in women of the Rotterdam Study (N=135) and GARP (N=98). Associations were examined using linear regression analyses, adjusted for age, fasting status, RNA quality, technical batch effects, blood cell counts, and BMI. To investigate enriched pathways and protein-protein interactions, we used the DAVID and STRING webtools.

Results

In a meta-analysis, we identified 257 probes mapping to 189 unique genes in blood that were nominally signifi

SUBMITTER: Peters MJ 

PROVIDER: S-EPMC4837985 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature