Response to stress in Drosophila is mediated by gender, age and stress paradigm.

ABSTRACT: All living organisms must maintain equilibrium in response to internal and external challenges within their environment. Changes in neural plasticity (alterations in neuronal populations, dendritic remodeling, and synaptic turnover) are critical components of the homeostatic response to stress, which has been strongly implicated in the onset of affective disorders. However, stress is differentially perceived depending on the type of stress and its context, as well as genetic background, age and sex; therefore, an individual's maintenance of neuronal homeostasis must differ depending upon these variables. We established Drosophila as a model to analyze homeostatic responses to stress. Sexually immature and mature females and males from an isogenic wild-type strain raised under controlled en

SUBMITTER: Neckameyer WS 

PROVIDER: S-EPMC4838016 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature