Paraneoplastic Neurological Syndromes and Glutamic Acid Decarboxylase Antibodies.

ABSTRACT:

Importance

Little is known of glutamic acid decarboxylase antibodies (GAD-abs) in the paraneoplastic context. Clinical recognition of such cases will lead to prompt tumor diagnosis and appropriate treatment.

Objective

To report the clinical and immunological features of patients with paraneoplastic neurological syndromes (PNS) and GAD-abs.

Design, setting, and participants

Retrospective case series study and immunological investigations conducted in February 2014 in a center for autoimmune neurological disorders. Fifteen cases with GAD65-abs evaluated between 1995 and 2013 who fulfilled criteria of definite or possible PNS without concomitant onconeural antibodies were included in this study.

Main outcomes and measures

Analysis of the clinical records of 15 pat

SUBMITTER: Arino H 

PROVIDER: S-EPMC4838033 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature