Baseline Chromatin Modification Levels May Predict Interindividual Variability in Ozone-Induced Gene Expression.

ABSTRACT: Traditional toxicological paradigms have relied on factors such as age, genotype, and disease status to explain variability in responsiveness to toxicant exposure; however, these are neither sufficient to faithfully identify differentially responsive individuals nor are they modifiable factors that can be leveraged to mitigate the exposure effects. Unlike these factors, the epigenome is dynamic and shaped by an individual's environment. We sought to determine whether baseline levels of specific chromatin modifications correlated with the interindividual variability in their ozone (O3)-mediated induction in an air-liquid interface model using primary human bronchial epithelial cells from a panel of 11 donors. We characterized the relationship between the baseline abundance of 6 epigenetic m

SUBMITTER: McCullough SD 

PROVIDER: S-EPMC4838038 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature