Thyroid dysfunction, thyroid hormone replacement and colorectal cancer risk.

ABSTRACT:

Background

Current screening guidelines for colorectal cancer (CRC) do not consider thyroid dysfunction as a risk factor for disease development. We sought to determine the risk of developing CRC in patients with thyroid dysfunction, with and without thyroid hormone replacement (THR).

Methods

We conducted a nested case-control study using a large population-based medical records database from the United Kingdom. Study case patients were defined as those with any medical code of CRC. Subjects with familial colorectal cancer syndromes or inflammatory bowel disease (IBD) were excluded. For every case patient, four eligible control patients matched on age, sex, practice site, and duration of follow-up before index date were selected using incidence density sampling. Exposure was

SUBMITTER: Boursi B 

PROVIDER: S-EPMC4838062 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature