Evidence for Accelerated Decline of Functional Brain Network Efficiency in Schizophrenia.

ABSTRACT: Previous work suggests that individuals with schizophrenia display accelerated aging of white matter integrity, however, it is still unknown whether functional brain networks also decline at an elevated rate in schizophrenia. Given the known degradation of functional connectivity and the normal decline in cognitive functioning throughout healthy aging, we aimed to test the hypothesis that efficiency of large-scale functional brain networks supporting overall cognition, as well as integrity of hub nodes within those networks, show evidence of accelerated aging in schizophrenia. Using pseudo-resting state data in 54 healthy controls and 46 schizophrenia patients, in which task-dependent signal from 3 tasks was regressed out to approximate resting-state data, we observed a significant diagnos

SUBMITTER: Sheffield JM 

PROVIDER: S-EPMC4838081 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature