Structural Brain Network Disturbances in the Psychosis Spectrum.

ABSTRACT:

Background

Individuals with subclinical psychotic symptoms provide a unique window on the pathophysiology of psychotic experiences as these individuals are free of confounders such as hospitalization, negative and cognitive symptoms and medication use. Brain network disturbances of white matter connections are thought to play a central role in the pathophysiology of psychosis. Based on the structural network disconnection hypothesis in schizophrenia, we expect less and weaker connections, and altered brain network organization in individuals with clinical and those with subclinical psychotic symptoms.

Methods

We used diffusion tensor imaging to study 35 patients with a psychotic disorder, 35 subjects with subclinical psychotic symptoms, and 36 healthy controls. The structura

SUBMITTER: van Dellen E 

PROVIDER: S-EPMC4838099 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature