Mapping Depression in Schizophrenia: A Functional Magnetic Resonance Imaging Study.

ABSTRACT: Depressive symptoms are common in schizophrenia, often left untreated, and associated with a high relapse rate, suicidal ideation, increased mortality, reduced social adjustment and poor quality of life. The neural mechanisms underlying depression in psychosis are poorly understood. Given reports of altered brain response to negative facial affect in depressive disorders, we examined brain response to emotive facial expressions in relation to levels of depression in people with psychosis. Seventy outpatients (final N= 63) and 20 healthy participants underwent functional magnetic resonance imaging during an implicit affect processing task involving presentation of facial expressions of fear, anger, happiness as well as neutral expressions and a (no face) control condition. All patients comp

SUBMITTER: Kumari V 

PROVIDER: S-EPMC4838102 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature