Benefits of polidocanol endovenous microfoam (Varithena®) compared with physician-compounded foams.

ABSTRACT:

Objective

To compare foam bubble size and bubble size distribution, stability, and degradation rate of commercially available polidocanol endovenous microfoam (Varithena®) and physician-compounded foams using a number of laboratory tests.

Methods

Foam properties of polidocanol endovenous microfoam and physician-compounded foams were measured and compared using a glass-plate method and a Sympatec QICPIC image analysis method to measure bubble size and bubble size distribution, Turbiscan™ LAB for foam half time and drainage and a novel biomimetic vein model to measure foam stability. Physician-compounded foams composed of polidocanol and room air, CO2, or mixtures of oxygen and carbon dioxide (O2:CO2) were generated by different methods.

Results

Polidocanol endovenous m

SUBMITTER: Carugo D 

PROVIDER: S-EPMC4838175 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature