Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis.

ABSTRACT:

Background

Active pulmonary tuberculosis is difficult to diagnose and treatment response is difficult to effectively monitor. A WHO consensus statement has called for new non-sputum diagnostics. The aim of this study was to use an integrated multicohort analysis of samples from publically available datasets to derive a diagnostic gene set in the peripheral blood of patients with active tuberculosis.

Methods

We searched two public gene expression microarray repositories and retained datasets that examined clinical cohorts of active pulmonary tuberculosis infection in whole blood. We compared gene expression in patients with either latent tuberculosis or other diseases versus patients with active tuberculosis using our validated multicohort analysis framework. Three datasets w

SUBMITTER: Sweeney TE 

PROVIDER: S-EPMC4838193 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature