The Heterogeneity in Retrieved Relations between the Personality Trait 'Harm Avoidance' and Gray Matter Volumes Due to Variations in the VBM and ROI Labeling Processing Settings.

ABSTRACT: Concerns are raising about the large variability in reported correlations between gray matter morphology and affective personality traits as 'Harm Avoidance' (HA). A recent review study (Mincic 2015) stipulated that this variability could come from methodological differences between studies. In order to achieve more robust results by standardizing the data processing procedure, as a first step, we repeatedly analyzed data from healthy females while changing the processing settings (voxel-based morphology (VBM) or region-of-interest (ROI) labeling, smoothing filter width, nuisance parameters included in the regression model, brain atlas and multiple comparisons correction method). The heterogeneity in the obtained results clearly illustrate the dependency of the study outcome to the opted a

SUBMITTER: Van Schuerbeek P 

PROVIDER: S-EPMC4838261 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature