A Bronchial Genomic Classifier for the Diagnostic Evaluation of Lung Cancer.

ABSTRACT:

Background

Bronchoscopy is frequently nondiagnostic in patients with pulmonary lesions suspected to be lung cancer. This often results in additional invasive testing, although many lesions are benign. We sought to validate a bronchial-airway gene-expression classifier that could improve the diagnostic performance of bronchoscopy.

Methods

Current or former smokers undergoing bronchoscopy for suspected lung cancer were enrolled at 28 centers in two multicenter prospective studies (AEGIS-1 and AEGIS-2). A gene-expression classifier was measured in epithelial cells collected from the normal-appearing mainstem bronchus to assess the probability of lung cancer.

Results

A total of 639 patients in AEGIS-1 (298 patients) and AEGIS-2 (341 patients) met the criteria for inclusio

SUBMITTER: Silvestri GA 

PROVIDER: S-EPMC4838273 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature