A Computational Model of the Rainbow Trout Hypothalamus-Pituitary-Ovary-Liver Axis.

ABSTRACT: Reproduction in fishes and other vertebrates represents the timely coordination of many endocrine factors that culminate in the production of mature, viable gametes. In recent years there has been rapid growth in understanding fish reproductive biology, which has been motivated in part by recognition of the potential effects that climate change, habitat destruction and contaminant exposure can have on natural and cultured fish populations. New approaches to understanding the impacts of these stressors are being developed that require a systems biology approach with more biologically accurate and detailed mathematical models. We have developed a multi-scale mathematical model of the female rainbow trout hypothalamus-pituitary-ovary-liver axis to use as a tool to help understand the function

SUBMITTER: Gillies K 

PROVIDER: S-EPMC4838294 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature