Does Viral Co-Infection Influence the Severity of Acute Respiratory Infection in Children?

ABSTRACT:

Background

Multiple viruses are often detected in children with respiratory infection but the significance of co-infection in pathogenesis, severity and outcome is unclear.

Objectives

To correlate the presence of viral co-infection with clinical phenotype in children admitted with acute respiratory infections (ARI).

Methods

We collected detailed clinical information on severity for children admitted with ARI as part of a Spanish prospective multicenter study (GENDRES network) between 2011-2013. A nested polymerase chain reaction (PCR) approach was used to detect respiratory viruses in respiratory secretions. Findings were compared to an independent cohort collected in the UK.

Results

204 children were recruited in the main cohort and 97 in the replication cohor

SUBMITTER: Cebey-Lopez M 

PROVIDER: S-EPMC4838299 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature