Ontology highlight
ABSTRACT:
SUBMITTER: Talhouk A
PROVIDER: S-EPMC4838303 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
PloS one 20160420 4
A major weakness in many high-throughput genomic studies is the lack of consideration of a clinical environment where one patient at a time must be evaluated. We examined generalizable and platform-specific sources of variation from NanoString gene expression data on both ovarian cancer and Hodgkin lymphoma patients. A reference-based strategy, applicable to single-patient molecular testing is proposed for batch effect correction. The proposed protocol improved performance in an established Hodg ...[more]