Interaction of Insulin Resistance and Related Genetic Variants With Triglyceride-Associated Genetic Variants.

ABSTRACT:

Background

Several studies suggest that some triglyceride-associated single-nucleotide polymorphisms (SNPs) have pleiotropic and opposite effects on glycemic traits. This potentially implicates them in pathways such as de novo lipogenesis, which is presumably upregulated in the context of insulin resistance. We therefore tested whether the association of triglyceride-associated SNPs with triglyceride levels differs according to one's level of insulin resistance.

Methods and results

In 3 cohort studies (combined n=12 487), we tested the interaction of established triglyceride-associated SNPs (individually and collectively) with several traits related to insulin resistance, on triglyceride levels. We also tested the interaction of triglyceride SNPs with fasting insulin-associa

SUBMITTER: Klimentidis YC 

PROVIDER: S-EPMC4838530 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature