Ontology highlight
ABSTRACT:
SUBMITTER: Lacar B
PROVIDER: S-EPMC4838832 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature communications 20160419
Single-cell sequencing methods have emerged as powerful tools for identification of heterogeneous cell types within defined brain regions. Application of single-cell techniques to study the transcriptome of activated neurons can offer insight into molecular dynamics associated with differential neuronal responses to a given experience. Through evaluation of common whole-cell and single-nuclei RNA-sequencing (snRNA-seq) methods, here we show that snRNA-seq faithfully recapitulates transcriptional ...[more]