A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder.

ABSTRACT:

Background

Social impairment is a defining feature of autism spectrum disorder (ASD) with no demonstrated effective pharmacologic treatments. The goal of this study was to evaluate efficacy, safety, and tolerability of oral N-acetylcysteine (NAC), an antioxidant whose function overlaps with proposed mechanisms of ASD pathophysiology, targeting core social impairment in youth with ASD.

Methods

This study was a 12-week randomized, double-blind, placebo-controlled trial of oral NAC in youth with ASD. Study participants were medically healthy youth age 4 to 12 years with ASD, weighing ≥15 kg, and judged to be moderately ill based on the Clinical Global Impressions Severity scale. The participants were randomized via computer to active drug or placebo in a 1:1 ratio, with the tar

SUBMITTER: Wink LK 

PROVIDER: S-EPMC4839099 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature