Brain and White Matter Hyperintensity Volumes After 10 Years of Random Assignment to Lifestyle Intervention.

ABSTRACT:

Objective

Type 2 diabetes increases the accumulation of brain white matter hyperintensities and loss of brain tissue. Behavioral interventions to promote weight loss through dietary changes and increased physical activity may delay these adverse consequences. We assessed whether participation in a successful 10-year lifestyle intervention was associated with better profiles of brain structure.

Research design and methods

At enrollment in the Action for Health in Diabetes clinical trial, participants had type 2 diabetes, were overweight or obese, and were aged 45-76 years. They were randomly assigned to receive 10 years of lifestyle intervention, which included group and individual counseling, or to a control group receiving diabetes support and education through group sessio

SUBMITTER: Espeland MA 

PROVIDER: S-EPMC4839171 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature