Metabolomics in Prediabetes and Diabetes: A Systematic Review and Meta-analysis.

ABSTRACT:

Objective

To conduct a systematic review of cross-sectional and prospective human studies evaluating metabolite markers identified using high-throughput metabolomics techniques on prediabetes and type 2 diabetes.

Research design and methods

We searched MEDLINE and EMBASE databases through August 2015. We conducted a qualitative review of cross-sectional and prospective studies. Additionally, meta-analyses of metabolite markers, with data estimates from at least three prospective studies, and type 2 diabetes risk were conducted, and multivariable-adjusted relative risks of type 2 diabetes were calculated per study-specific SD difference in a given metabolite.

Results

We identified 27 cross-sectional and 19 prospective publications reporting associations of metabolites

SUBMITTER: Guasch-Ferre M 

PROVIDER: S-EPMC4839172 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature