Unknown

Dataset Information

0

RhesusBase PopGateway: Genome-Wide Population Genetics Atlas in Rhesus Macaque.


ABSTRACT: Although population genetics studies have significantly accelerated the evolutionary and functional interrogations of genes and regulations, limited polymorphism data are available for rhesus macaque, the model animal closely related to human. Here, we report the first genome-wide effort to identify and visualize the population genetics profile in rhesus macaque. On the basis of the whole-genome sequencing of 31 independent macaque animals, we profiled a comprehensive polymorphism map with 46,146,548 sites. The allele frequency for each polymorphism site, the haplotype structure, as well as multiple population genetics parameters were then calculated on a genome-wide scale. We further developed a specific interface, the RhesusBase PopGateway, to facilitate the visualization of these annotations, and highlighted the applications of this highly integrative platform in clarifying the selection signatures of genes and regulations in the context of the primate evolution. Overall, the updated RhesusBase provides a comprehensive monkey population genetics framework for in-depth evolutionary studies of human biology.

SUBMITTER: Zhong X 

PROVIDER: S-EPMC4839223 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

altmetric image

Publications

RhesusBase PopGateway: Genome-Wide Population Genetics Atlas in Rhesus Macaque.

Zhong Xiaoming X   Peng Jiguang J   Shen Qing Sunny QS   Chen Jia-Yu JY   Gao Han H   Luan Xuke X   Yan Shouyu S   Huang Xin X   Zhang Shi-Jian SJ   Xu Luying L   Zhang Xiuqin X   Tan Bertrand Chin-Ming BC   Li Chuan-Yun CY  

Molecular biology and evolution 20160216 5


Although population genetics studies have significantly accelerated the evolutionary and functional interrogations of genes and regulations, limited polymorphism data are available for rhesus macaque, the model animal closely related to human. Here, we report the first genome-wide effort to identify and visualize the population genetics profile in rhesus macaque. On the basis of the whole-genome sequencing of 31 independent macaque animals, we profiled a comprehensive polymorphism map with 46,14  ...[more]

Similar Datasets

| S-EPMC2659879 | biostudies-literature
| S-EPMC6467493 | biostudies-literature
| S-EPMC4512905 | biostudies-literature
| S-EPMC10569716 | biostudies-literature
| S-EPMC9738698 | biostudies-literature
| S-EPMC8223001 | biostudies-literature
2024-09-24 | GSE277821 | GEO
| PRJNA675026 | ENA
| S-EPMC6981234 | biostudies-literature
| S-EPMC5870573 | biostudies-literature