Effect of in-painting on cortical thickness measurements in multiple sclerosis: A large cohort study.

ABSTRACT: A comprehensive analysis of the effect of lesion in-painting on the estimation of cortical thickness using magnetic resonance imaging was performed on a large cohort of 918 relapsing-remitting multiple sclerosis patients who participated in a phase III multicenter clinical trial. An automatic lesion in-painting algorithm was developed and implemented. Cortical thickness was measured using the FreeSurfer pipeline with and without in-painting. The effect of in-painting was evaluated using FreeSurfer's paired analysis pipeline. Multivariate regression analysis was also performed with field strength and lesion load as additional factors. Overall, the estimated cortical thickness was different with in-painting than without. The effect of in-painting was observed to be region dependent, more sig

SUBMITTER: Govindarajan KA 

PROVIDER: S-EPMC4839289 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature