Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma.

ABSTRACT: B-cell responses are emerging as critical regulators of cancer progression. In this study, we investigated the role of B lymphocytes in the microenvironment of human pancreatic ductal adenocarcinoma (PDAC), in a retrospective consecutive series of 104 PDAC patients and in PDAC preclinical models. Immunohistochemical analysis revealed that B cells occupy two histologically distinct compartments in human PDAC, either scatteringly infiltrating (CD20-TILs), or organized in tertiary lymphoid tissue (CD20-TLT). Only when retained within TLT, high density of B cells predicted longer survival (median survival 16.9 mo CD20-TLT^hi vs. 10.7 mo CD20-TLT^lo; p = 0.0085). Presence of B cells within TLT associated to a germinal center (GC) immune signature, correlated with CD8-

SUBMITTER: Castino GF 

PROVIDER: S-EPMC4839336 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature