Ontology highlight
ABSTRACT:
SUBMITTER: Yang PY
PROVIDER: S-EPMC4839405 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Yang Peng-Yu PY Zou Huafei H Chao Elizabeth E Sherwood Lance L Nunez Vanessa V Keeney Michael M Ghartey-Tagoe Esi E Ding Zhongli Z Quirino Herlinda H Luo Xiaozhou X Welzel Gus G Chen Guohua G Singh Parminder P Woods Ashley K AK Schultz Peter G PG Shen Weijun W
Proceedings of the National Academy of Sciences of the United States of America 20160328 15
Antidiabetic treatments aiming to reduce body weight are currently gaining increased interest. Exendin-4, a glucagon-like peptide-1 (GLP-1) receptor agonist administered twice daily via s.c. injection, improves glycemic control, often with associated weight reduction. To further improve the therapeutic efficacy of exendin-4, we have developed a novel peptide engineering strategy that incorporates a serum protein binding motif onto a covalent side-chain staple and applied to the peptide to enhanc ...[more]