Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes.

ABSTRACT: Y chromosomes control essential male functions in many species, including sex determination and fertility. However, because of obstacles posed by repeat-rich heterochromatin, knowledge of Y chromosome sequences is limited to a handful of model organisms, constraining our understanding of Y biology across the tree of life. Here, we leverage long single-molecule sequencing to determine the content and structure of the nonrecombining Y chromosome of the primary African malaria mosquito, Anopheles gambiae We find that the An. gambiae Y consists almost entirely of a few massively amplified, tandemly arrayed repeats, some of which can recombine with similar repeats on the X chromosome. Sex-specific genome resequencing in a recent species radiation, the An. gambiae complex, revealed rapid sequenc

SUBMITTER: Hall AB 

PROVIDER: S-EPMC4839409 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature