Reward Responsiveness Varies by Smoking Status in Women with a History of Major Depressive Disorder.

ABSTRACT: Major depressive disorder (MDD) and nicotine dependence are highly comorbid, with studies showing that ~50% of individuals with MDD smoke. The link between these disorders persists even after the clinical symptoms of depression subside, as indicated by high levels of nicotine dependence among individuals with remitted depression (rMDD). Recent evidence indicates that individuals with rMDD show blunted responses to reward as measured by a probabilistic reward task (PRT), which assesses the ability to modify behavior as a function of reward history. Given nicotine's ability to enhance reward responsiveness, individuals with rMDD might smoke to address this persistent reward deficit. However, it is unclear whether smokers with rMDD show enhanced reward responsiveness relative to rMDD individu

SUBMITTER: Janes AC 

PROVIDER: S-EPMC4839517 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature