Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke.

ABSTRACT:

Background and purpose

White matter hyperintensities (WMH) are increased in patients with lacunar stroke. Whether this is because of shared pathogenesis remains unknown. Using genetic data, we evaluated whether WMH-associated genetic susceptibility factors confer risk of lacunar stroke, and therefore whether they share pathogenesis.

Methods

We used a genetic risk score approach to test whether single nucleotide polymorphisms associated with WMH in community populations were associated with magnetic resonance imaging-confirmed lacunar stroke (n=1,373), as well as cardioembolic (n=1,331) and large vessel (n=1,472) Trial of Org 10172 in Acute Stroke Treatment subtypes, against 9,053 controls. Second, we separated lacunar strokes into those with WMH (n=568) and those without (n=

SUBMITTER: Traylor M 

PROVIDER: S-EPMC4839546 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature