Circulating MicroRNA Responses between 'High' and 'Low' Responders to a 16-Wk Diet and Exercise Weight Loss Intervention.

ABSTRACT:

Background

Interactions between diet, physical activity and genetic predisposition contribute to variable body mass changes observed in response to weight loss interventions. Circulating microRNAs (c-miRNAs) may act as 'biomarkers' that are associated with the rate of change in weight loss, and/or play a role in regulating the biological variation, in response to energy restriction.

Objective

To quantify targeted c-miRNAs with putative roles in energy metabolism and exercise adaptations following a 16 wk diet and exercise intervention in individuals with large (high responders; HiRes) versus small (low responders; LoRes) losses in body mass.

Methods

From 89 male and female overweight/obese participants who completed the intervention (energy restriction from diet, 250

SUBMITTER: Parr EB 

PROVIDER: S-EPMC4839646 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature