Trisomy 21 Alters DNA Methylation in Parent-of-Origin-Dependent and -Independent Manners.

ABSTRACT: The supernumerary chromosome 21 in Down syndrome differentially affects the methylation statuses at CpG dinucleotide sites and creates genome-wide transcriptional dysregulation of parental alleles, ultimately causing diverse pathologies. At present, it is unknown whether those effects are dependent or independent of the parental origin of the nondisjoined chromosome 21. Linkage analysis is a standard method for the determination of the parental origin of this aneuploidy, although it is inadequate in cases with deficiency of samples from the progenitors. Here, we assessed the reliability of the epigenetic 5mCpG imprints resulting in the maternally (oocyte)-derived allele methylation at a differentially methylated region (DMR) of the candidate imprinted WRB gene for asserting the parental or

SUBMITTER: Alves da Silva AF 

PROVIDER: S-EPMC4839675 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature