Effect of Statins on the Progression of Coronary Calcification in Kidney Transplant Recipients.

ABSTRACT:

Background

Coronary calcification (CAC) is highly prevalent in kidney transplant recipients (KTRs) and has been associated with cardiovascular morbidity and mortality. Some studies have shown a reduction in CAC progression with statin therapy in the general and chronic kidney disease (CKD) populations.

Objectives and methods

The aim of the present study was to evaluate the effect of statins on CAC progression in incident kidney transplant recipients. Patients were randomly assigned to the statin (n = 61, 10 mg daily) and control group (n = 59). CAC and biochemical analyses were performed at baseline and 12 months.

Results

At baseline, CAC was observed in 30% and 21% of patients in the statin and control groups, respectively (p = 0.39). The calcium score at baseline an

SUBMITTER: Yazbek DC 

PROVIDER: S-EPMC4839705 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature