Serum folate, vitamin B-12 and cognitive function in middle and older age: The HAPIEE study.

ABSTRACT:

Background

Nutrient status of B vitamins, particularly folate and vitamin B-12, may be related to cognitive ageing but epidemiological evidence remains inconclusive.

Objective

The aim of this study was to estimate the association of serum folate and vitamin B-12 concentrations with cognitive function in middle-aged and older adults from three Central and Eastern European populations.

Methods

Men and women aged 45-69 at baseline participating in the Health, Alcohol and Psychosocial factors in Eastern Europe (HAPIEE) study were recruited in Krakow (Poland), Kaunas (Lithuania) and six urban centres in the Czech Republic. Tests of immediate and delayed recall, verbal fluency and letter search were administered at baseline and repeated in 2006-2008. Serum concentrations of

SUBMITTER: Horvat P 

PROVIDER: S-EPMC4839985 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature