Antipsychotic Medication for Prevention and Treatment of Delirium in Hospitalized Adults: A Systematic Review and Meta-Analysis.

ABSTRACT:

Objectives

To evaluate the effectiveness of antipsychotic medications in preventing and treating delirium.

Design

Systematic review and meta-analysis.

Setting

PubMed, EMBASE, CINAHL, and ClinicalTrials.gov databases were searched from January 1, 1988, to November 26, 2013.

Participants

Adult surgical and medical inpatients.

Intervention

Antipsychotic administration for delirium prevention or treatment in randomized controlled trials or cohort studies.

Measurements

Two authors independently reviewed all citations, extracted relevant data, and assessed studies for potential bias. Heterogeneity was considered as chi-square P < .1 or I(2) > 50%. Using a random-effects model (I(2) > 50%) or a fixed-effects model (I(2) < 50%), odds ratios (ORs) were cal

SUBMITTER: Neufeld KJ 

PROVIDER: S-EPMC4840067 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature