Effects of Vitamin D3 Supplementation on Lean Mass, Muscle Strength, and Bone Mineral Density During Weight Loss: A Double-Blind Randomized Controlled Trial.

ABSTRACT:

Objectives

To compare the effects of 12 months of vitamin D3 supplementation with that placebo on lean mass, bone mineral density (BMD), and muscle strength in overweight or obese postmenopausal women completing a structured weight-loss program.

Design

Double-blind, placebo-controlled randomized clinical trial.

Setting

Fred Hutchinson Cancer Research Center, Seattle, Washington.

Participants

Postmenopausal women aged 50 to 75 with a body mass index (BMI) of 25 kg/m(2) or greater and a serum 25-hydroxyvitamin D (25(OH)D) concentration between 10.0 and 32.0 ng/mL (insufficient) (N = 218).

Intervention

Oral vitamin D3 2,000 IU/d or placebo in combination with a lifestyle-based weight loss intervention consisting of a reduction of 500 kcal to 1,000 kcal per

SUBMITTER: Mason C 

PROVIDER: S-EPMC4840082 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature